One can recollect in chronological order the different moments of the day, with details on spatial locations, time, people and actions involved. This form of memory, called “episodic memory”, is supported by structures of the temporal lobe, in particular the hippocampus. It is hypothesized that links between high-level representations such as ‘location’, ‘objects’ and ‘actions’ are continuously created and stored within the hippocampus and adjacent cortical areas. This ongoing storage would be the initial stage of memory encoding, and would be followed by a stage of memory consolidation, in which salient informations are redistributed to other brain areas, making memory less dependent on hippocampal regions. Consistent with this idea, old memories are the most resilient to hippocampal lesions or diseases such as Alzheimer. 

    We are interested in the network dynamics supporting the encoding, retrieval and consolidation of episodic memory. Our main approach is to monitor and manipulate (using optogenetic) the neural activity in the hippocampus and connected areas while mice are performing specific behavioral

tasks. To this end, we use the

following technologies:

  1. -Silicon probes for recording

LFP and neural spikes

  1. -Optrodes to combine

recordings and optogenetic

stimulations

  1. -Treadmills, in which mice

perform well controlled

foraging behaviors in 1-D

landscapes

Research interest

Network dynamics supporting episodic memory

Silicon probe with integrated fibers (optrode)